Phthalic acid and derivatives
Apexbio Technology LLC Cyclic Pifithrin-α hydrobromide 511296-88-1 10mg
Cyclic Pifithrin- hydrobromide (CAS 511296-88-1) is a synthetic small molecule that functions as an inhibitor of the tumor suppressor protein p53 By blocking p53-dependent transcriptional activation of response genes it interferes with p53-mediated cellular processes such as apoptosis and cell cycle arrest In vitro Cyclic Pifithrin- hydrobromide inhibits p53-dependent apoptosis and DNA damage-induced growth arrest in various cell models without notable effects on p53-deficient cells In vivo it protects mice from the toxic side effects of genotoxic cancer therapies likely through suppression of p53-dependent pathways This compound is utilized in research investigating p53 biology cellular stress responses and modulation of chemotherapeutic toxicity
TARGETMOL CHEMICALS INC CK-636 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. CK-636 (CK-0944636) an Arp2/3 complex inhibitor can inhibit actin polymerization induced by the human (IC50 4 uM) fission yeast (IC50 24 uM) and bovine (IC50 32 uM) Arp2/3 complex respectively. purity: 98%
Medchemexpress LLC Cyclic AMP-13C5 (Cyclic adenosine monophosphate-13C5) | 2170095-23-3 | 97.5% | 1 MG
Cyclic AMP-13C5 is a deuterated cyclic AMP. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Contains stable heavy isotopes.
eMolecules 1679-64-7 | mono-Methyl Terephthalate | Accela ChemBio (ASD) | MFCD00002557 | 180.159 | C9H8O4 | 98.000 | COC(=O)c1ccc(cc1)C(O)=O | 5g | 444755831
mono-Methyl Terephthalate | Accela ChemBio (ASD) | 1679-64-7 | MFCD00002557 | 180.159 | C9H8O4 | 98.000 | COC(=O)c1ccc(cc1)C(O)=O | 5g | 444755831
Apexbio Technology LLC Cyclic di-GMP(Synonyms: Cyclic diguanylate, c-di-GMP, diguanylate cyclase product), 500ug, CAS: 61093-23-0.
Cyclic di-GMP (CAS 61093-23-0) is an intracellular second messenger involved in diverse bacterial physiological processes including biofilm formation motility and pathogenicity It functions in mammalian cells as an agonist for Stimulator of Interferon Genes (STING) directly binding and activating it to induce innate immune responses Due to this mechanism cyclic di-GMP serves as a valuable tool for investigating STING-mediated immune modulation pathways and has research applications in cancer immunotherapy studies notably enhancing antitumor immunity in metastatic melanoma models
Medchemexpress LLC Cyclic AMP sodium | 37839-81-9 | 99.97% | 250 MG
Cyclic AMP (Cyclic adenosine monophosphate) sodium, an adenosine triphosphate derivative, is an intracellular signaling molecule that directs cellular responses to extracellular signals. It acts as an important second messenger in many biological processes. It also modulates mediator generation, suppressing the expression of pro-inflammatory cytokines and enhancing the production of anti-inflammatory cytokine.
- Acts as an important second messenger
- Modulates mediator generation
- Suppresses pro-inflammatory cytokines like TNF-α and IL-12
- Enhances anti-inflammatory cytokine IL-10 production
TARGETMOL CHEMICALS INC BAY 61-3606 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. BAY 61-3606 (Syk inhibitor IV) is a potent ATP-competitive reversible and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) exhibiting no inhibitory effect against Btk Fyn Itk Lyn and Src. purity: 98%
Medchemexpress LLC Guanosine, cyclic 3',5'-(hydrogen phosphate) (TBAOH) | 99.1% | 604.68 | 10 MG
Cyclic GMP (cGMP) TBAOH is an important second messenger and a major intracellular mediator of extracellular signals like nitric oxide (NO) and natriuretic peptides (NPs). Its effects are mediated through cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses.
- Important second messenger
- Intracellular mediator of extracellular signals (nitric oxide and natriuretic peptides)
- Inhibits both platelet adhesion and aggregation
- Can activate cGMP-mediated protein kinases
- Can activate cGMP-stimulated phosphodiesterases when acting synergistically with Isoprenaline, reversing cAMP-mediated enhancement or inhibiting cAMP-induced inward calcium current (ICa)
Medchemexpress LLC Desethyl dabigatran etexilate | 212321-78-3 | 599.68 | 25 MG
Desethyl Dabigatran Etexilate is an intermediate metabolite of dabigatran etexilate, primarily used for research purposes. This compound is supplied as a white to yellow solid.
- Intermediate metabolite
- For research use only
- White to yellow solid appearance
- Stable as powder at -20°C for 3 years, or 4°C for 2 years
- Stable in solvent at -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC Cyclic adenosine monophosphate | 60-92-4 | 99.9% | 10 G
Cyclic AMP (Cyclic adenosine monophosphate) is a derivative of adenosine triphosphate and functions as an intracellular signaling molecule, directing cellular responses to extracellular signals. It is recognized as an important second messenger in numerous biological processes. Cyclic AMP modulates mediator generation by suppressing the expression of pro-inflammatory cytokines, such as TNF-α and IL-12, while enhancing the production of the anti-inflammatory cytokine IL-10.
- Intracellular signaling molecule
- Directs cellular responses to extracellular signals
- Functions as an important second messenger in biological processes
- Modulates mediator generation
- Suppresses pro-inflammatory cytokines
- Enhances anti-inflammatory cytokine production
eMolecules 940895-85-2 | 6-(TRIFLUOROMETHOXY)NICOTINIC ACID | AstaTech | MFCD17677182 | 207.108 | C7H4F3NO3 | 95.000 | OC(=O)c1ccc(OC(F)(F)F)nc1 | 0.05g | 857176031
6-(TRIFLUOROMETHOXY)NICOTINIC ACID | AstaTech | 940895-85-2 | MFCD17677182 | 207.108 | C7H4F3NO3 | 95.000 | OC(=O)c1ccc(OC(F)(F)F)nc1 | 0.05g | 857176031
Medchemexpress LLC Croconic acid disod 50mg
Croconic acid (disodium) (Nacr) can promote cell growth and proliferation by enhancing the expression of genes associated with lysine crotonylation (Kcr) modification Croconic acid holds potential for improving somatic cell nuclear transfer (SCNT) efficiency and optimizing cell culture conditions research[1]
Medchemexpress LLC Sulbenicillin disodium | 28002-18-8 | 50 MG
Sulbenicillin disodium is the disodium salt of Sulbenicillin. Sulbenicillin is a Penicillin antibiotic that exhibits antibacterial activity against various mucoid and non-mucoid strains of Pseudomonas aeruginosa.
- Purity: 98.84%
- Molecular Weight: 458.42
- Formula: C16H16N2Na2O7S2
- Appearance: Solid
- Color: White to off-white
- Storage: 4°C, sealed storage, away from moisture
- In-solvent storage: -80°C for 6 months or -20°C for 1 month, sealed and away from moisture
- Solubility in H2O: 250 mg/mL (requires sonication)
- Solubility in PBS: 100 mg/mL (clear solution; requires sonication)
Aobchem 1-Hexaneboronic acid cyclic iminodiethylene ester | ≥95% | CAS 96472-47-8 | C10H22BNO2 | 250mg
1-Hexaneboronic acid cyclic iminodiethylene ester | ≥95% | CAS 96472-47-8 | C10H22BNO2 | 250mg
Medchemexpress LLC Adenosine 3',5'-cyclic monophosphate | 60-92-4 | MFCD00005845 | 99.9% | 329.21 g/mol | C10H12N5O6P | 10 MG
Cyclic adenosine monophosphate (adenosine 3',5'-cyclic monophosphate; cAMP) is provided as an analytical standard for use as a calibration or reference material in quantitative biochemical and analytical assays. The material is supplied in a 10 mg vial and is intended for method development and accurate quantification of cAMP.
- Analytical standard for quantitative assays.
- High purity: 99.9% (typical).
- Suitable for HPLC, LC-MS, and ELISA calibration.
- Molecular weight 329.21 g/mol; CAS 60-92-4.